Pnpla7 Gene Summary [Mouse]
Enables lysophospholipase activity. Involved in phosphatidylcholine catabolic process. Located in endoplasmic reticulum membrane and lipid droplet. Is expressed in several structures, including central nervous system; germ cell of testis; and retina nuclear layer. Orthologous to human PNPLA7 (patatin like phospholipase domain containing 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pnpla7 |
| Official Name | patatin-like phospholipase domain containing 7 [Source:MGI Symbol;Acc:MGI:2385325] |
| Ensembl ID | ENSMUSG00000036833 |
| Bio databases IDs | |
| Aliases | patatin-like phospholipase domain containing 7 |
| Synonyms | C9orf111, E430013P11Rik, LOC100911867, Nre, Ntel, NTEL1, NTE-R1, Nte-related, patatin-like phospholipase domain containing 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pnpla7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Patatins and Phospholipases
- Cyclic nucleotide-binding domain
- lysophospholipase
- enzyme
- Cyclic nucleotide-monophosphate binding domain
- CAP_ED
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- lipid droplets
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pnpla7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylcholine catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- lipid particle
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity