Arhgef26 Gene Summary [Mouse]
Acts upstream of or within endothelial cell morphogenesis and ruffle assembly. Is expressed in pons ventricular layer. Orthologous to human ARHGEF26 (Rho guanine nucleotide exchange factor 26). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgef26 |
| Official Name | Rho guanine nucleotide exchange factor (GEF) 26 [Source:MGI Symbol;Acc:MGI:1918053] |
| Ensembl ID | ENSMUSG00000036885 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor (GEF) 26 |
| Synonyms | 4631416L12Rik, 8430436L14Rik, HMFN1864, RGD1562559, Rho guanine nucleotide exchange factor 26, SGEF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgef26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- PH domain
- Pleckstrin homology-like domain
- PDZ binding motif
- Dbl homology domain
- RhoGEF domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Arhgef26 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- schizophrenia
- coronary artery disease
- atherosclerosis
- myocardial infarction
- aortic stenosis
role in cell
- morphology
- abnormal morphology
- assembly
- function
- invasiveness
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoskeleton
- cytosol
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgef26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ruffle assembly
- endothelial cell morphogenesis
Cellular Component
Where in the cell the gene product is active
- ruffle
- cytosol
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity