C1qc Gene Summary [Mouse]
Involved in synapse pruning. Located in postsynapse. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic membrane and extrinsic component of presynaptic membrane. Is expressed in blood vessel; dentate gyrus subgranular zone; and retina. Orthologous to human C1QC (complement C1q C chain). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | C1qc |
| Official Name | complement component 1, q subcomponent, C chain [Source:MGI Symbol;Acc:MGI:88225] |
| Ensembl ID | ENSMUSG00000036896 |
| Bio databases IDs | |
| Aliases | complement component 1, q subcomponent, C chain |
| Synonyms | Adib, C1QD3, C1QG, Ciqc, complement C1q C chain, complement component 1, q subcomponent, C chain |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse C1qc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Collagen triple helix repeat (20 copies)
- protein binding
- globular head domain
- C1q domain
Pathways
Biological processes and signaling networks where the C1qc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
- keloid
- organismal death
- complement component C1q deficiency type 3
- osteoarthritis
- complement component C1q deficiency
- laser induced choroidal neovascularization
- colorectal cancer
- diabetic nephropathy
regulates
- S
role in cell
- differentiation
- pruning
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- postsynaptic region
- Plasma Membrane
- synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse C1qc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- negative regulation of macrophage differentiation
- complement activation, classical pathway
- innate immune response
- negative regulation of granulocyte differentiation
Cellular Component
Where in the cell the gene product is active
- complement component C1 complex
- extracellular space
- collagen
- blood microparticle
- synapse
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding