Trpv6 Gene Summary [Mouse]
Enables calcium channel activity and identical protein binding activity. Involved in calcium ion homeostasis; calcium ion import across plasma membrane; and response to calcium ion. Acts upstream of or within calcium ion transport and parathyroid hormone secretion. Part of calcium channel complex. Is expressed in several structures, including central nervous system; extraembryonic component; gut; sensory organ; and submandibular gland primordium. Human ortholog(s) of this gene implicated in hyperparathyroidism. Orthologous to human TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trpv6 |
| Official Name | transient receptor potential cation channel, subfamily V, member 6 [Source:MGI Symbol;Acc:MGI:1927259] |
| Ensembl ID | ENSMUSG00000029868 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel, subfamily V, member 6 |
| Synonyms | ABP/ZF, Cac, CAT, CAT1, CATL, Crac, ECAC2, HRPTTN, HSA277909, LP6728, Otrpc3, transient receptor potential cation channel subfamily V member 6, transient receptor potential cation channel, subfamily V, member 6, ZFAB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trpv6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium activated cation channel
- Ankyrin repeats (many copies)
- Ion transport protein
- calmodulin binding
- calcium channel
- Ankyrin repeats (3 copies)
- protein binding
- identical protein binding
- ion channel
- Ankyrin repeat
- transient-receptor-potential calcium channel protein
- Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Trpv6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- neoplasia
- epithelial cancer
- cancer
- hepatocellular carcinoma
- liver cancer
- transient neonatal hyperparathyroidism
- alcoholic pancreatitis
- mastocytosis
role in cell
- quantity
- cell viability
- morphology
- proliferation
- apoptosis
- migration
- motility
- cell-cell contact
- store-operated calcium influx in
- stratification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical compartment
- cellular membrane
- Nucleus
- vesicles
- apical cell surfaces
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trpv6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion homeostasis
- response to calcium ion
- calcium ion transport
- calcium ion transmembrane transport
- regulation of calcium ion-dependent exocytosis
- parathyroid hormone secretion
Cellular Component
Where in the cell the gene product is active
- calcium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- identical protein binding
- protein binding
- metal ion binding
- calcium channel activity