Evl Gene Summary [Mouse]
Enables SH3 domain binding activity and profilin binding activity. Involved in actin polymerization or depolymerization and positive regulation of actin filament polymerization. Acts upstream of or within cellular response to type II interferon. Located in focal adhesion; lamellipodium; and phagocytic vesicle. Is expressed in several structures, including central nervous system; genitourinary system; immune system; liver; and retina. Orthologous to human EVL (Enah/Vasp-like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Evl |
| Official Name | Ena-vasodilator stimulated phosphoprotein [Source:MGI Symbol;Acc:MGI:1194884] |
| Ensembl ID | ENSMUSG00000021262 |
| Bio databases IDs | |
| Aliases | Ena-vasodilator stimulated phosphoprotein |
| Synonyms | AI528774, b2b2600Clo, Enah/Vasp-like, Ena-vasodilator stimulated phosphoprotein, RNB6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Evl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WH2
- protein binding
- Pleckstrin homology-like domain
- zDHHC ankyrin repeat binding domain
- proline rich domain
- SH3-domain binding
- profilin binding
- VASP tetramerization domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic periodontal disease
- white matter hyperintensities
- familial adenomatous polyposis
role in cell
- migration
- expression in
- proliferation
- number
- cell-matrix adhesion
- trafficking
- response by
- durotaxis by
- assembly
- internalization by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- focal adhesions
- cytosol
- filopodial tip
- phagosomes
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Evl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- actin polymerization or depolymerization
- positive regulation of stress fiber assembly
- positive regulation of actin filament polymerization
- negative regulation of epithelial cell migration
- nervous system development
- actin filament organization
- cell surface receptor signaling pathway
- negative regulation of ruffle assembly
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- membrane
- stress fiber
- cytosol
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- SH3 domain binding
- profilin binding