Fdps Gene Summary [Mouse]
Predicted to enable (2E,6E)-farnesyl diphosphate synthase activity and dimethylallyltranstransferase activity. Predicted to be involved in farnesyl diphosphate biosynthetic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of cholesterol biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fdps |
| Official Name | farnesyl diphosphate synthetase [Source:MGI Symbol;Acc:MGI:104888] |
| Ensembl ID | ENSMUSG00000059743 |
| Bio databases IDs | |
| Aliases | farnesyl diphosphate synthetase |
| Synonyms | 6030492I17Rik, Ac2-125, FARNESYL DIPHOSPHATE SYNTHASE, farnesyl diphosphate synthetase, FARNESYL PYROPHOSPHATE SYNTHASE, Fdps1, Fdpsl1, FPPS, FPP SYNTHASE, FPP synthetase, FPS, KIAA1293, mKIAA1293, POROK9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fdps often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- geranyltranstransferase
- Isoprenoid Biosynthesis enzymes, Class 1
- dimethylallyltranstransferase
- Polyprenyl synthetase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Fdps gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- plasma cell myeloma
- adult solid tumor
- pneumonia
- lymphoma
- cystic fibrosis
- diabetes mellitus
- epithelial cancer
- metastasis
- breast adenocarcinoma
role in cell
- production in
- proliferation
- phosphorylation in
- expression in
- replication in
- formation in
- cellular infiltration by
- fluidity
- downregulation in
- stimulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- mitochondrial matrix
- nucleoplasm
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fdps gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- geranyl diphosphate biosynthetic process
- cholesterol biosynthetic process
- farnesyl diphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- geranyltranstransferase activity
- RNA binding
- protein binding
- metal ion binding
- dimethylallyltranstransferase activity