Cavin3 Gene Summary [Mouse]
Enables protein kinase C binding activity. Involved in circadian regulation of gene expression. Acts upstream of or within cortical actin cytoskeleton organization; negative regulation of fermentation; and regulation of intracellular signal transduction. Located in caveola and cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; heart valve; and integumental system. Orthologous to human CAVIN3 (caveolae associated protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cavin3 |
| Official Name | caveolae associated 3 [Source:MGI Symbol;Acc:MGI:1923422] |
| Ensembl ID | ENSMUSG00000037060 |
| Bio databases IDs | |
| Aliases | caveolae associated 3 |
| Synonyms | 3110015B12Rik, 6330514M23RIK, caveolae associated 3, caveolae associated protein 3, DIG-2, HSRBC, PRKCDBP, SRBC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cavin3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase C binding
- leucine zipper domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- osteoarthritis
- hepatic steatosis
- lipodystrophy
- cachexia
role in cell
- apoptosis
- proliferation
- G1 phase
- respiration in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- caveolae-derived endocytic vesicles
- cell surface
- endosomes
- vesicles
- caveolae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cavin3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cortical actin cytoskeleton organization
- circadian regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- caveola
- cytoplasm
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- protein binding