Brcc3 Gene Summary [Mouse]
Enables metal-dependent deubiquitinase activity. Involved in chromatin remodeling; positive regulation of NLRP3 inflammasome complex assembly; and protein K63-linked deubiquitination. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Is expressed in central nervous system and genitourinary system. Orthologous to human BRCC3 (BRCA1/BRCA2-containing complex subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brcc3 |
| Official Name | BRCA1/BRCA2-containing complex, subunit 3 [Source:MGI Symbol;Acc:MGI:2389572] |
| Ensembl ID | ENSMUSG00000031201 |
| Bio databases IDs | |
| Aliases | BRCA1/BRCA2-containing complex, subunit 3 |
| Synonyms | B36, BRCA1/BRCA2-containing complex subunit 3, BRCA1/BRCA2-containing complex, subunit 3, BRCC36, C6.1A, CXorf53 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brcc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BRCC36 C-terminal helical domain
- metallopeptidase
- Mpr1p, Pad1p N-terminal (MPN) domains
- peptidase
- enzyme
- protein binding
- enzyme regulator activity
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Brcc3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe hemophilia A and moyamoya syndrome
- X-linked Moyamoya disease
- venous thromboembolism
role in cell
- phosphorylation in
- production in
- expression in
- apoptosis
- activation in
- proliferation
- cell death
- invasion by
- G2/M phase
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brcc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- mitotic cell cycle G2/M transition DNA damage checkpoint
- response to X-ray
- regulation of DNA repair
- positive regulation of NLRP3 inflammasome complex assembly
- double-strand break repair
- cell division
- proteolysis
- cellular response to ionizing radiation
- regulation of DNA damage checkpoint
- protein K63-linked deubiquitination
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear ubiquitin ligase complex
- ubiquitin ligase complex
- cytoplasm
- BRISC complex
- spindle pole
- cytosol
- BRCA1-A complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- metal ion binding
- polyubiquitin binding
- enzyme regulator activity
- metallopeptidase activity