Il16 Gene Summary [Mouse]
Enables cytokine activity. Involved in cytokine-mediated signaling pathway. Acts upstream of or within several processes, including induction of positive chemotaxis; positive regulation of chemokine production; and positive regulation of neutrophil activation. Located in collagen-containing extracellular matrix. Is expressed in several structures, including foregut; jaw; limb; respiratory system; and vibrissa. Human ortholog(s) of this gene implicated in asthma; colorectal adenocarcinoma; and prostate cancer. Orthologous to human IL16 (interleukin 16). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il16 |
| Official Name | interleukin 16 [Source:MGI Symbol;Acc:MGI:1270855] |
| Ensembl ID | ENSMUSG00000001741 |
| Bio databases IDs | |
| Aliases | interleukin 16 |
| Synonyms | interleukin 16, LCF, lymphocyte chemoattractant factor, mKIAA4048, NIL16, PRIL16 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- nuclear localization sequence
- canonical PDZ domain
- protein binding
- cytokine
- PDZ domain
- cpPDZ_Deg_HtrA-like
- pro domain
- CD4 receptor binding
Pathways
Biological processes and signaling networks where the Il16 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- peripheral arterial disease
- cardiac fibrosis
- systemic lupus erythematosus
- sarcoidosis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- tuberculosis
role in cell
- proliferation
- survival
- formation
- migration
- function
- production in
- cellular infiltration by
- chemotaxis
- recruitment
- chemoattraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell periphery
- intracellular space
- perinuclear region
- focal adhesions
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- actomyosin filament
- Flemming body
- cytosol
- perinuclear space
- nuclear speckles
- neurites
- myosin stress fibers
- actin stress fibers
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of interleukin-12 production
- immune response
- signal transduction
- positive regulation of inflammatory response
- positive regulation of interleukin-1 alpha production
- leukocyte chemotaxis
- regulation of calcium ion transport
- positive regulation of interleukin-6 production
- induction of positive chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- focal adhesion
- nuclear speck
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- CD4 receptor binding
- cytokine activity