Plekhg2 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in regulation of actin filament polymerization. Orthologous to human PLEKHG2 (pleckstrin homology and RhoGEF domain containing G2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekhg2 |
| Official Name | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 [Source:MGI Symbol;Acc:MGI:2141874] |
| Ensembl ID | ENSMUSG00000037552 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 |
| Synonyms | ARHGEF42, CLG, Cslg, CTB-60E11.4, FLJ00018, LDAMD, pleckstrin homology and RhoGEF domain containing G2, pleckstrin homology domain containing, family G (with RhoGef domain) member 2, RGD1310112 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekhg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- protein binding
- Pleckstrin homology-like domain
- Dbl homology domain
- RhoGEF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- leukodystrophy and acquired microcephaly
- leukodystrophy and acquired microcephaly without dystonia
regulates
- CDC42
- RAC
role in cell
- cell viability
- cell spreading
- polymerization
- transformation
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekhg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding