Atoh8 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity and DNA-binding transcription factor binding activity. Involved in formation of primary germ layer; myoblast proliferation; and negative regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart and pericardium; and respiratory system. Orthologous to human ATOH8 (atonal bHLH transcription factor 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Atoh8 |
| Official Name | atonal bHLH transcription factor 8 [Source:MGI Symbol;Acc:MGI:1918343] |
| Ensembl ID | ENSMUSG00000037621 |
| Bio databases IDs | |
| Aliases | atonal bHLH transcription factor 8 |
| Synonyms | 4933425C05Rik, atonal bHLH transcription factor 8, Atonal homolog 8 (d. melanogaster), bHLHa21, HATH6, Math6, okadin, RGD1561512 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atoh8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- transcription factor binding
- protein binding
- Helix-loop-helix DNA-binding domain
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- abdominal aortic aneurysm
role in cell
- expression in
- migration
- maturation
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atoh8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- anatomical structure morphogenesis
- positive regulation of endothelial cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- myoblast proliferation
- formation of primary germ layer
- cell differentiation
- negative regulation of endothelial cell proliferation
- positive regulation of SMAD protein import into nucleus
- tube formation
- positive regulation of endothelial cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- E-box binding