Themis2 Gene Summary [Mouse]
Involved in regulation of B cell activation. Acts upstream of or within T cell receptor signaling pathway. Located in cytoplasm and nucleus. Orthologous to human THEMIS2 (thymocyte selection associated family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Themis2 |
| Official Name | thymocyte selection associated family member 2 [Source:MGI Symbol;Acc:MGI:2446213] |
| Ensembl ID | ENSMUSG00000037731 |
| Bio databases IDs | |
| Aliases | thymocyte selection associated family member 2 |
| Synonyms | C1orf38, ICB-1, LOC100360356, RGD1561016, thymocyte selection associated family member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Themis2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cell-cycle sustaining, positive selection,
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- liver cancer
- hepatocellular carcinoma
- complete testicular feminization syndrome
- uterine serous papillary cancer
role in cell
- expression in
- proliferation
- phosphorylation in
- invasion by
- migration
- epithelial-mesenchymal transition
- adhesion
- development
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Themis2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- cell adhesion
- T cell receptor signaling pathway
- regulation of B cell activation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding