Spock1 Gene Summary [Mouse]
Predicted to enable several functions, including calcium ion binding activity; collagen binding activity; and endopeptidase inhibitor activity. Involved in central nervous system neuron differentiation and neuron migration. Located in neuromuscular junction; node of Ranvier; and sarcoplasm. Is active in postsynaptic density. Is expressed in several structures, including jaw; nervous system; sensory organ; skeletal musculature; and thymus primordium. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spock1 |
| Official Name | sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 [Source:MGI Symbol;Acc:MGI:105371] |
| Ensembl ID | ENSMUSG00000056222 |
| Bio databases IDs | |
| Aliases | sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 |
| Synonyms | LOC102549404, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1, sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1, SPOCK, TESTICAN, TESTICAN1, TIC1, TICN1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spock1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EFh_SPARC_EC
- cysteine protease inhibitor activity
- TY
- calcium ion binding
- EFh
- Secreted protein acidic and rich in cysteine Ca binding region
- protein binding
- metalloendopeptidase inhibitor
- KAZAL_FS
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- cough
- generalized epilepsy
- organismal death
- epithelial cancer
- COVID-19
- metabolic syndrome X
- bronchopulmonary dysplasia
- Rett syndrome
- human immunodeficiency virus I infection
role in cell
- expression in
- cell death
- apoptosis
- migration
- invasion by
- proliferation
- development
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- sarcoplasm
- nodes of Ranvier
- neuromuscular junctions
- extracellular matrix
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spock1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- negative regulation of cell-substrate adhesion
- negative regulation of neuron projection development
- regulation of cell growth
- nervous system development
- negative regulation of endopeptidase activity
- central nervous system neuron differentiation
- neurogenesis
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- extracellular space
- sarcoplasm
- cytoplasm
- node of Ranvier
- neuromuscular junction
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding
- cysteine-type endopeptidase inhibitor activity
- calcium ion binding
- metalloendopeptidase inhibitor activity