Mapk4 Gene Summary [Mouse]
Enables protein heterodimerization activity; protein homodimerization activity; and protein kinase binding activity. Predicted to be involved in intracellular signal transduction. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; genitourinary system; nasal epithelium; stomach; and thymus. Orthologous to human MAPK4 (mitogen-activated protein kinase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Mapk4 |
| Official Name | mitogen-activated protein kinase 4 [Source:MGI Symbol;Acc:MGI:2444559] |
| Ensembl ID | ENSMUSG00000024558 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase 4 |
| Synonyms | A330097D03Rik, ERK3, ERK-4, Mitogen activated protein kinase 4, p63-MAPK, PRKM4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mapk4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- protein kinase binding
- Protein Kinases, catalytic domain
- MAP kinase
- protein homodimerization
- protein binding
- Protein kinase domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Mapk4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiomyocyte Signaling Pathway
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- FAK Signaling
- Neuroinflammation Signaling Pathway
- Opioid Signaling Pathway
- Phagosome Formation
- Role of Tissue Factor in Cancer
- Sirtuin Signaling Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- endometriosis
role in cell
- quantity
- expression in
- phosphorylation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mapk4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- MAP kinase activity
- protein serine/threonine kinase activity