Kdm1b Gene Summary [Mouse]
Enables FAD-dependent H3K4me/H3K4me3 demethylase activity; flavin adenine dinucleotide binding activity; and zinc ion binding activity. Involved in genomic imprinting. Acts upstream of or within epigenetic programing of female pronucleus. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human KDM1B (lysine demethylase 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kdm1b |
| Official Name | lysine (K)-specific demethylase 1B [Source:MGI Symbol;Acc:MGI:2145261] |
| Ensembl ID | ENSMUSG00000038080 |
| Bio databases IDs | |
| Aliases | lysine (K)-specific demethylase 1B |
| Synonyms | 4632428N09Rik, AOF1, C6orf193, LSD2, lysine demethylase 1B, lysine (K)-specific demethylase 1B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kdm1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding
- protoporphyrinogen oxidase
- histone binding
- CW-type Zinc Finger
- flavin adenine dinucleotide binding
- zinc ion binding
- SWIRM domain
- enzyme
- protein binding
- paired donor oxygen oxidoreductase
- histone demethylase activity
- Flavin containing amine oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- atrial fibrillation
role in cell
- DNA methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleosomes
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kdm1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- genetic imprinting
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- FAD binding
- zinc ion binding
- protein binding
- histone binding
- oxidoreductase activity
- flavin adenine dinucleotide binding
- histone demethylase activity
- transcription factor binding
- chromatin binding