Phf20 Gene Summary [Mouse]
Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be part of MLL1 complex and NSL complex. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human PHF20 (PHD finger protein 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phf20 |
| Official Name | PHD finger protein 20 [Source:MGI Symbol;Acc:MGI:2444148] |
| Ensembl ID | ENSMUSG00000038116 |
| Bio databases IDs | |
| Aliases | PHD finger protein 20 |
| Synonyms | 6820402O20Rik, C20orf104, GLEA2, HCA58, NZF, PHD finger protein 20, RGD1305020, TDRD20A, TZP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phf20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF3776)
- PHD zinc finger
- transcription regulator
- DNA repair protein Crb2 Tudor domain
- Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
- PHD finger superfamily
- protein binding
- Tudor domain superfamily
- malignant brain tumor (MBT) repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- migraines
- non-melanoma skin cancer
- osteoarthritis
- cardioembolic stroke
- systemic juvenile idiopathic arthritis
- breast carcinoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phf20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytosol
- NSL complex
- MLL1 complex
- histone acetyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding