Slamf7 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within regulation of natural killer cell activation. Located in external side of plasma membrane. Orthologous to human SLAMF7 (SLAM family member 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slamf7 |
| Official Name | SLAM family member 7 [Source:MGI Symbol;Acc:MGI:1922595] |
| Ensembl ID | ENSMUSG00000038179 |
| Bio databases IDs | |
| Aliases | SLAM family member 7 |
| Synonyms | 19A, 19A24, 4930560D03Rik, CD319, CRACC, CS1, RGD1560190, Slam7, SLAM family member 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slamf7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- protein binding
- identical protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- multiple sclerosis
- liver cancer
- COVID-19
- light chain only multiple myeloma
- refractory multiple myeloma
- secretory multiple myeloma
- plasma cell myeloma
- lymphoma
role in cell
- expression in
- phagocytosis by
- proliferation
- migration
- activation in
- lysis
- cellular infiltration by
- phagocytosis
- cytotoxicity
- killing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Endoplasmic Reticulum
- cell-cell contacts
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slamf7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell activation
- adaptive immune response
- natural killer cell activation
- cell adhesion
- natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding