Syne1 Gene Summary [Mouse]
Enables actin filament binding activity and protein homodimerization activity. Involved in centrosome localization and regulation of cilium assembly. Acts upstream of or within nuclear migration. Located in nuclear envelope. Is expressed in several structures, including alimentary system; ear; genitourinary system; musculoskeletal system; and nervous system. Used to study Emery-Dreifuss muscular dystrophy. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita (multiple); bipolar disorder; cerebellar ataxia (multiple); and muscular dystrophy (multiple). Orthologous to human SYNE1 (spectrin repeat containing nuclear envelope protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syne1 |
| Official Name | spectrin repeat containing, nuclear envelope 1 [Source:MGI Symbol;Acc:MGI:1927152] |
| Ensembl ID | ENSMUSG00000096054 |
| Bio databases IDs | |
| Aliases | spectrin repeat containing, nuclear envelope 1 |
| Synonyms | 8B, A330049M09Rik, AMC3, AMCM, ARCA1, C130039F11Rik, C6orf98, CPG2, dJ45H2.2, EDMD4, KASH1, LOC102546492, LOC103690962, mKIAA1756, MYNE1, Nesp1, NESPRIN-1, SCAR8, spectrin repeat containing, nuclear envelope 1, spectrin repeat containing nuclear envelope protein 1, Synaptic Nuclei Expressed Gene1 β, SYNE-1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Syne1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Calponin homology domain
- protein binding activity, bridging
- lamin binding
- enzyme binding
- protein binding
- receptor binding
- identical protein binding
- actin filament binding
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- Spectrin repeats
- Nuclear envelope localization domain
- actin binding
- KASH domain
- Spectrin repeat
- protein homodimerization
- calponin homology (CH) domain superfamily
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- bipolar disorder
- major depression
- myogenic type arthrogryposis multiplex congenita
- uterine leiomyoma
- leiomyomatosis
- spinocerebellar ataxia recessive 8
- bipolar I disorder
- COVID-19
- schizophrenia
regulates
- glutamate receptor (family)
role in cell
- migration
- proliferation
- apoptosis
- cell death
- organization
- assembly
- abnormal morphology
- differentiation
- morphogenesis
- rotation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- GW body
- glutaminergic synapse
- cytoplasmic mRNA processing body
- cytoskeleton
- Cytoplasm
- perinuclear region
- cellular membrane
- focal adhesions
- actin cytoskeleton
- Golgi Apparatus
- Endoplasmic Reticulum
- microtubules
- midbody
- sarcomere
- postsynaptic membrane
- nucleoplasm
- nucleoli
- nuclear envelope
- dendritic spines
- dendritic spine head
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Syne1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mesenchymal cell apoptotic process
- spermatogenesis
- Golgi organization
- muscle cell differentiation
- positive regulation of mesenchymal cell proliferation
- nuclear matrix anchoring at nuclear membrane
- positive regulation of receptor-mediated endocytosis
- cardiac muscle cell differentiation
- nucleus organization
- response to light stimulus
- regulation of dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- cytoplasmic mRNA processing body
- Golgi apparatus
- nuclear outer membrane
- nucleolus
- dendritic spine head
- nucleoplasm
- nuclear envelope
- nucleus
- nuclear membrane
- perinuclear region of cytoplasm
- cytoskeleton
- cytoplasm
- postsynaptic membrane
- membrane
- midbody
- SUN-KASH complex
- sarcomere
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- RNA binding
- protein homodimerization activity
- actin binding
- lamin binding
- receptor binding
- enzyme binding