Cer1 Gene Summary [Mouse]
Enables protein homodimerization activity. Involved in several processes, including growth plate cartilage chondrocyte proliferation; negative regulation of mesoderm development; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including cellular response to cadmium ion; negative regulation of BMP signaling pathway; and signal transduction involved in regulation of gene expression. Located in extracellular space. Is expressed in several structures, including alimentary system; blastocyst; brain; genitourinary system; and paraxial mesenchyme. Orthologous to human CER1 (cerberus 1, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cer1 |
| Official Name | cerberus 1, DAN family BMP antagonist [Source:MGI Symbol;Acc:MGI:1201414] |
| Ensembl ID | ENSMUSG00000038192 |
| Bio databases IDs | |
| Aliases | cerberus 1, DAN family BMP antagonist |
| Synonyms | CERBERUS, cerberus 1, DAN family BMP antagonist, Cerl, Cerl1, Cerr1, DAND4, RGD1563046 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cer1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- morphogen
- cytokine binding
- protein homodimerization
- cytokine
- DAN domain
Pathways
Biological processes and signaling networks where the Cer1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cer1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone mineralization
- determination of heart left/right asymmetry
- negative regulation of cell proliferation
- negative regulation of mesoderm development
- sequestering of BMP in extracellular matrix
- signal transduction involved in regulation of gene expression
- nervous system development
- anterior/posterior pattern specification
- gastrulation
- negative regulation of BMP signaling pathway
- anterior/posterior axis specification
- determination of dorsal identity
- ureteric bud development
- cell migration involved in gastrulation
- negative regulation of activin receptor signaling pathway
- growth plate cartilage chondrocyte proliferation
- cellular response to cadmium ion
- negative regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- BMP binding
- protein homodimerization activity
- cytokine activity
- morphogen activity