Mrc2 Gene Summary [Mouse]
Predicted to enable carbohydrate binding activity; collagen binding activity; and signaling receptor activity. Predicted to be involved in collagen catabolic process. Predicted to be located in cell surface. Is expressed in several structures, including brain; head bone; meninges; metanephros; and respiratory system. Orthologous to human MRC2 (mannose receptor C-type 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Mrc2 |
| Official Name | mannose receptor, C type 2 [Source:MGI Symbol;Acc:MGI:107818] |
| Ensembl ID | ENSMUSG00000020695 |
| Bio databases IDs | |
| Aliases | mannose receptor, C type 2 |
| Synonyms | CD280, CLEC13E, ENDO180, mannose receptor C-type 2, mannose receptor, C type 2, mKIAA0709, TEM9, UPARAP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mrc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ricin-type beta-trefoil
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- beta-trefoil_Ricin_MRC-like
- collagen binding
- protein binding
- carbohydrate binding
- FN2
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Mrc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic obstructive pulmonary disease
- metastasis
- glioblastoma
- abdominal aortic aneurysm
- atrial fibrillation
- aortic aneurysm
- migraines
- glioblastoma cancer
- coronary artery disease
role in cell
- expression in
- proliferation
- apoptosis
- migration
- invasion by
- binding
- endocytosis by
- migration by
- contractility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mrc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoblast differentiation
- collagen catabolic process
- endocytosis
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- collagen binding
- signaling receptor activity
- carbohydrate binding