Bcl9 Gene Summary [Mouse]
Enables beta-catenin binding activity. Acts upstream of or within several processes, including canonical Wnt signaling pathway; myotube differentiation involved in skeletal muscle regeneration; and skeletal muscle cell differentiation. Located in cis-Golgi network; nucleus; and sarcoplasm. Is expressed in several structures, including brain; eye; head surface ectoderm; metanephros; and thymus primordium. Orthologous to human BCL9 (BCL9 transcription coactivator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcl9 |
| Official Name | B cell CLL/lymphoma 9 [Source:MGI Symbol;Acc:MGI:1924828] |
| Ensembl ID | ENSMUSG00000038256 |
| Bio databases IDs | |
| Aliases | B cell CLL/lymphoma 9 |
| Synonyms | 2610202E01RIK, 8030475K17Rik, A330041G23Rik, B cell CLL/lymphoma 9, BCL9 transcription coactivator, BCL9, transcription coactivator, Gm130, LGS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcl9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BCL9 homology domain
- beta-catenin binding
- B-cell lymphoma 9 protein
- protein binding
- HD2 domain
Pathways
Biological processes and signaling networks where the Bcl9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- schizophrenia
- congenital hypothyroidism
- chronic obstructive pulmonary disease
- hand-foot syndrome
- congenital heart disease
- intellectual disability and developmental delay
- infection by HIV-1
role in cell
- proliferation
- cellular infiltration by
- invasion
- migration
- differentiation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear Golgi regions
- Golgi Apparatus
- sarcoplasm
- cis Golgi networks
- nucleoplasm
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcl9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myotube differentiation involved in skeletal muscle regeneration
- skeletal muscle cell differentiation
- somatic stem cell maintenance
- myoblast differentiation
- canonical Wnt receptor signaling pathway
- transcription from RNA polymerase II promoter
- regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cis-Golgi network
- sarcoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- beta-catenin binding