Bcl2l13 Gene Summary [Mouse]
Acts upstream of or within several processes, including canonical glycolysis; fat cell differentiation; and mitophagy. Is active in mitochondrion. Orthologous to human BCL2L13 (BCL2 like 13). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcl2l13 |
| Official Name | BCL2-like 13 (apoptosis facilitator) [Source:MGI Symbol;Acc:MGI:2136959] |
| Ensembl ID | ENSMUSG00000009112 |
| Bio databases IDs | |
| Aliases | BCL2-like 13 (apoptosis facilitator) |
| Synonyms | BCL2 like 13, BCL-RAMBO, E430016C20Rik, MIL1, ZD77D08 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcl2l13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bcl-2_like
- Bcl-2 homology 1 domain
- membrane-association domain
- Bcl-2 homology 2 domain
- Bcl-2 homology 3 domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- acute myeloid leukemia
- glioblastoma cancer
- glioma cancer
- glioma formation
- central nervous system cancer
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- CD30 positive anaplastic large cell lymphoma
- glioblastoma
role in cell
- differentiation
- organization
- apoptosis
- activation in
- mitochondrial membrane permeabilization
- mitochondrial membrane permeabilization in
- glycolysis in
- mitophagy in
- homodimerization in
- oxidative phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcl2l13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- regulation of apoptotic process
- activation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial membrane
- membrane
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- cysteine-type endopeptidase activator activity involved in apoptotic process