Sema7a Gene Summary [Mouse]
Enables integrin binding activity. Involved in several processes, including integrin-mediated signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of macrophage cytokine production. Acts upstream of or within nervous system development; positive regulation of axon extension; and positive regulation of protein phosphorylation. Located in external side of plasma membrane. Is active in GABA-ergic synapse and presynapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human SEMA7A (semaphorin 7A (JohnMiltonHagen blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Sema7a |
| Official Name | sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A [Source:MGI Symbol;Acc:MGI:1306826] |
| Ensembl ID | ENSMUSG00000038264 |
| Bio databases IDs | |
| Aliases | sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A |
| Synonyms | 2900057C09RIK, CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, M-Sema-L, PFIC11, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A, SEMAK1, SEMAL, semaphorin 7A (John Milton Hagen blood group) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- semaphorin domain
- Plexin repeat
- immunoglobulin domain
- integrin binding
- RGD motif
- protein binding
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema7a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- neoplasia
- epithelial cancer
- osteoarthritis
- progressive familial intrahepatic cholestasis type 11
- liver cancer
- hepatic steatosis
- hepatocellular carcinoma
- infection
- proliferative diabetic retinopathy
role in cell
- apoptosis
- expression in
- activation in
- phosphorylation in
- morphogenesis
- accumulation
- growth
- motility
- extension
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
- synapse
- membrane rafts
- presynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema7a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- olfactory lobe development
- axon guidance
- positive regulation of axon extension
- positive regulation of macrophage cytokine production
- integrin-mediated signaling pathway
- inflammatory response
- immune response
- neural crest cell migration
- axon extension
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- osteoblast differentiation
- regulation of inflammatory response
- semaphorin-plexin signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- integrin binding
- chemorepellent activity
- semaphorin receptor binding