Pmepa1 Gene Summary [Mouse]
Predicted to enable R-SMAD binding activity and WW domain binding activity. Involved in negative regulation of SMAD protein signal transduction and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in endosome membrane. Predicted to be active in Golgi membrane and early endosome membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Orthologous to human PMEPA1 (prostate transmembrane protein, androgen induced 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pmepa1 |
| Official Name | prostate transmembrane protein, androgen induced 1 [Source:MGI Symbol;Acc:MGI:1929600] |
| Ensembl ID | ENSMUSG00000038400 |
| Bio databases IDs | |
| Aliases | prostate transmembrane protein, androgen induced 1 |
| Synonyms | 2210418I02Rik, Erg1.2, N4wbp4, prostate transmembrane protein, androgen induced 1, STAG1, TMEPA1, TMEPAI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pmepa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- WW domain binding
- protein binding
- proline tyrosine motif
Pathways
Biological processes and signaling networks where the Pmepa1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- preeclampsia
- survival
- Huntington disease
- organismal death
- adenomyosis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- peritoneal endometriosis
- familial adenomatous polyposis
role in cell
- apoptosis
- growth
- proliferation
- expression in
- migration
- binding in
- phosphorylation in
- degradation in
- invasion by
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear Golgi regions
- cellular membrane
- Golgi membrane
- endosomal membrane
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pmepa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of SMAD protein import into nucleus
- androgen receptor signaling pathway
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- intracellular membrane-bounded organelle
- membrane
- endosome membrane
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- R-SMAD binding
- WW domain binding