Otud7b Gene Summary [Mouse]
Enables K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Involved in several processes, including negative regulation of canonical NF-kappaB signal transduction; negative regulation of transcription by RNA polymerase II; and protein K48-linked deubiquitination. Acts upstream of or within in utero embryonic development and protein deubiquitination. Located in cytoplasm. Orthologous to human OTUD7B (OTU deubiquitinase 7B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Otud7b |
| Official Name | OTU domain containing 7B [Source:MGI Symbol;Acc:MGI:2654703] |
| Ensembl ID | ENSMUSG00000038495 |
| Bio databases IDs | |
| Aliases | OTU domain containing 7B |
| Synonyms | 2900060B22RIK, 4930463P07RIK, AI462125, CEZANNE, Cezanne-1, LOC105371427, OTU deubiquitinase 7B, OTU domain containing 7B, RGD1308111, Trabid2, ZA20D1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Otud7b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- cysteine-type peptidase
- UBA-like domain
- catalytic domain
- peptidase
- ubiquitin-specific protease
- A20-like zinc finger
- protein binding
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- breast carcinoma
- experimental autoimmune encephalomyelitis
- hypertension
- organismal death
- experimental cerebral malaria
- lobular breast carcinoma in situ
- lobular in situ neoplasia
- breast ductal carcinoma in situ
- ductal in situ breast cancer
role in cell
- expression in
- activation in
- synthesis in
- binding in
- phosphorylation in
- differentiation
- survival
- formation
- migration
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Otud7b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein localization to nucleus
- protein deubiquitination involved in ubiquitin-dependent protein catabolic process
- protein K11-linked deubiquitination
- adaptive immune response
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- mucosal immune response
- negative regulation of transcription from RNA polymerase II promoter
- in utero embryonic development
- negative regulation of interleukin-8 production
- proteolysis
- protein K63-linked deubiquitination
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- DNA binding
- zinc ion binding
- protein binding
- K63-linked polyubiquitin binding
- cysteine-type peptidase activity