Polr3k Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in termination of RNA polymerase III transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including 1st branchial arch; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 21. Orthologous to human POLR3K (RNA polymerase III subunit K). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polr3k |
| Official Name | polymerase (RNA) III (DNA directed) polypeptide K [Source:MGI Symbol;Acc:MGI:1914255] |
| Ensembl ID | ENSMUSG00000038628 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) III (DNA directed) polypeptide K |
| Synonyms | 12.3kDa, 1500004O14RIK, C11, C11-RNP3, HLD21, LOC246270, My010, polymerase (RNA) III (DNA directed) polypeptide K, RNA polymerase III subunit K, RPC10, RPC11, RPC12.5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr3k often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- zinc ion binding
- transcription factor S, archaeal
- DNA-directed RNA polymerase
- Zn-ribbon
- RNA polymerases M/15 Kd subunit
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr3k gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase III promoter
- innate immune response
- defense response to virus
- termination of RNA polymerase III transcription
Cellular Component
Where in the cell the gene product is active
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- RNA polymerase III activity
- zinc ion binding
- DNA-directed RNA polymerase activity
- protein binding