POLR3K Gene Summary [Human]
This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.[provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | POLR3K |
| Official Name | RNA polymerase III subunit K [Source:HGNC Symbol;Acc:HGNC:14121] |
| Ensembl ID | ENSG00000161980 |
| Bio databases IDs | |
| Aliases | RNA polymerase III subunit K |
| Synonyms | 12.3kDa, 1500004O14RIK, C11, C11-RNP3, HLD21, LOC246270, My010, polymerase (RNA) III (DNA directed) polypeptide K, RNA polymerase III subunit K, RPC10, RPC11, RPC12.5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR3K often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- zinc ion binding
- transcription factor S, archaeal
- DNA-directed RNA polymerase
- Zn-ribbon
- RNA polymerases M/15 Kd subunit
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR3K gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase III promoter
- innate immune response
- defense response to virus
- termination of RNA polymerase III transcription
Cellular Component
Where in the cell the gene product is active
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- RNA polymerase III activity
- zinc ion binding
- DNA-directed RNA polymerase activity
- protein binding