Rnh1 Gene Summary [Mouse]
Predicted to enable ribonuclease inhibitor activity. Predicted to be involved in cell migration; regulation of Arp2/3 complex-mediated actin nucleation; and regulation of angiogenesis. Predicted to be located in cytosol. Predicted to be part of angiogenin-PRI complex. Predicted to be active in several cellular components, including lamellipodium; nucleoplasm; and plasma membrane. Is expressed in bladder; blood; embryo; pancreas; and yolk sac. Orthologous to human RNH1 (ribonuclease/angiogenin inhibitor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnh1 |
| Official Name | ribonuclease/angiogenin inhibitor 1 [Source:MGI Symbol;Acc:MGI:1195456] |
| Ensembl ID | ENSMUSG00000038650 |
| Bio databases IDs | |
| Aliases | ribonuclease/angiogenin inhibitor 1 |
| Synonyms | IIAE12, PLACENTAL RIBONUCLEASE INHIBITOR, PRI, RAI, ribonuclease/angiogenin inhibitor 1, RNH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonuclease inhibitor
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat, ribonuclease inhibitor type
- Capping Ribonuclease inhibitor Leucine Rich Repeat
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- growth failure
- susceptibility to infection-induced acute encephalitis type 12
- anemia
- Sengers syndrome
- infection by HIV-1
role in cell
- proliferation
- migration
- differentiation
- number
- abnormal morphology
- molecular cleavage in
- assembly
- movement
- movement in
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of angiogenesis
- mRNA catabolic process
- cell migration
- regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- angiogenin-PRI complex
- cytosol
- plasma membrane
- nucleoplasm
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- ribonuclease inhibitor activity