Ercc6l Gene Summary [Mouse]
Predicted to enable DNA translocase activity. Predicted to be involved in DNA repair. Predicted to be located in kinetochore. Is expressed in several structures, including adrenal medulla; liver; lung; nervous system; and trunk. Orthologous to human ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ercc6l |
| Official Name | excision repair cross-complementing rodent repair deficiency complementation group 6 like [Source:MGI Symbol;Acc:MGI:2654144] |
| Ensembl ID | ENSMUSG00000051220 |
| Bio databases IDs | |
| Aliases | excision repair cross-complementing rodent repair deficiency complementation group 6 like |
| Synonyms | D330021P09Rik, ERCC excision repair 6 like, spindle assembly checkpoint helicase, excision repair cross-complementing rodent repair deficiency complementation group 6 like, PICH, RAD26L, RGD1565734 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ercc6l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA translocase
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- SNF2-related domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- breast cancer
- diffuse large B-cell lymphoma
- hepatocellular carcinoma
- organismal death
- liver cancer
- epithelial cancer
- epithelial uterine cancer
- chromophobe renal cell carcinoma
- chromophobe renal cancer
role in cell
- proliferation
- apoptosis
- cell death
- function
- replicative senescence
- abnormal morphology
- missegregation
- instability
- spindle checkpoint
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centromeric thread
- cytosol
- kinetochores
- chromosomal arms
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ercc6l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- chromatin remodeling
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- kinetochore
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- ATP binding
- protein binding
- DNA translocase activity
- helicase activity