Vars2 Gene Summary [Mouse]
Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and tail. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to human VARS2 (valyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vars2 |
| Official Name | valyl-tRNA synthetase 2, mitochondrial [Source:MGI Symbol;Acc:MGI:1916165] |
| Ensembl ID | ENSMUSG00000038838 |
| Bio databases IDs | |
| Aliases | valyl-tRNA synthetase 2, mitochondrial |
| Synonyms | 1190004I24RIK, COXPD20, mKIAA1885, Syvm, VALRS, valyl-tRNA synthetase 2, mitochondrial, VARS2L, VARSL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vars2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucyl-tRNA synthetase, eubacterial and mitochondrial family
- valine-tRNA ligase
- enzyme
- protein binding
- nucleotidyl transferase superfamily
- valyl-tRNA synthetase
- Anticodon-binding domain of tRNA ligase
- class Ia aminoacyl tRNA synthetases anticodon binding domain
- tRNA synthetases class I (I, L, M and V)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- combined oxidative phosphorylation deficiency 20
- mitochondrial disorder
- lung squamous cell carcinoma
- squamous cell lung cancer
- chronic obstructive pulmonary disease
- inguinal hernia
- microalbuminuria
- hypothyroidism
role in cell
- cell death
- autophagy in
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vars2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- valyl-tRNA aminoacylation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- valine-tRNA ligase activity
- ATP binding
- protein binding
- aminoacyl-tRNA editing activity