Rab1a Gene Summary [Mouse]
Predicted to enable GTP binding activity and GTPase activity. Involved in cell migration; melanosome transport; and substrate adhesion-dependent cell spreading. Located in Golgi apparatus and melanosome. Is expressed in several structures, including diaphragm and genitourinary system. Used to study dilated cardiomyopathy. Orthologous to human RAB1A (RAB1A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab1a |
| Official Name | RAB1A, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:97842] |
| Ensembl ID | ENSMUSG00000020149 |
| Bio databases IDs | |
| Aliases | RAB1A, member RAS oncogene family |
| Synonyms | Ac2-048, Gtbp, mKIAA3012, RAB1, RAB1A, member RAS oncogene family, Rab1p, Rab1r, YPT1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- alpha helix
- GTPase
- enzyme
- guanine nucleotide binding domain
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rab1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- liver cancer
- non-insulin-dependent diabetes mellitus
- prostate cancer
- brain cancer
- lung cancer
- preeclampsia
- renal cancer
- placental cancer
role in cell
- formation
- growth
- accumulation in
- autophagy in
- formation in
- binding in
- contraction
- fragmentation
- hypertrophy
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- membrane fraction
- intracellular nanovesicle
- endoplasmic reticulum mitochondria contact site
- cytoplasmic vesicle membrane
- exocytic vesicle
- presynaptic regions
- perinuclear region
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- cis face of the Golgi apparatus
- Golgi membrane
- synapse
- early endosomes
- melanosomes
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- rough microsomes
- perikaryon
- dendrites
- pre-Golgi intermediate vesicles
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- Golgi organization
- cargo loading into COPII-coated vesicle
- endocytosis
- intracellular protein transport
- defense response to bacterium
- autophagic vacuole assembly
- positive regulation of interleukin-8 production
- ER to Golgi vesicle-mediated transport
- vesicle-mediated transport
- autophagy
- vesicle transport along microtubule
- substrate adhesion-dependent cell spreading
- growth hormone secretion
- virion assembly
- cell migration
- melanosome transport
Cellular Component
Where in the cell the gene product is active
- early endosome
- transport vesicle membrane
- extracellular vesicular exosome
- melanosome
- cytosol
- endomembrane system
- endoplasmic reticulum
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- cadherin binding
- small monomeric GTPase activity