Zfp750 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Acts upstream of or within establishment of skin barrier; membrane biogenesis; and positive regulation of biosynthetic process. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; ganglia; salivary gland primordium; sensory organ; and skin. Orthologous to human ZNF750 (zinc finger protein 750). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp750 |
| Official Name | zinc finger protein 750 [Source:MGI Symbol;Acc:MGI:2442210] |
| Ensembl ID | ENSMUSG00000039238 |
| Bio databases IDs | |
| Aliases | zinc finger protein 750 |
| Synonyms | A030007D23Rik, FLJ13841, SLDPE, ZFP750, zinc finger protein 750 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp750 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc-finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- double-stranded DNA binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- dermatitis
- seborrhia-like dermatitis
role in cell
- expression in
- growth
- proliferation
- invasiveness
- adhesion
- migration
- cell focus formation by
- recruitment in
- methylation in
- biogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp750 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of epithelial to mesenchymal transition
- positive regulation of gene expression
- epidermis development
- cell differentiation
- positive regulation of ceramide biosynthetic process
- positive regulation of transcription from RNA polymerase II promoter
- establishment of skin barrier
- membrane biogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription