Trim56 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in several processes, including defense response to other organism; positive regulation of interferon-beta production; and protein ubiquitination. Located in cytoplasm. Orthologous to human TRIM56 (tripartite motif containing 56). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim56 |
| Official Name | tripartite motif-containing 56 [Source:MGI Symbol;Acc:MGI:2685298] |
| Ensembl ID | ENSMUSG00000043279 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 56 |
| Synonyms | A130009K11Rik, Gm452, LOC100044233, RNF109, tripartite motif-containing 56 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim56 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- protein binding
- NHL repeat unit of beta-propeller proteins
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- B-box zinc finger
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma cancer
- glioma formation
- immunodeficiency
- head and neck neoplasia
- glioma
- glioblastoma
- postmenopausal osteoporosis
- infection by HIV-1
- infection by Dengue virus 2
- infection by Yellow fever virus 17D
role in cell
- proliferation
- apoptosis
- expression in
- colony formation by
- invasion by
- Gap 0-Gap 1 phase
- replication in
- polyubiquitination in
- K48 polyubiquitination in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- granules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim56 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of innate immune response
- innate immune response
- positive regulation of interferon-beta production
- response to type I interferon
- positive regulation of type I interferon-mediated signaling pathway
- protein K63-linked ubiquitination
- defense response to virus
- protein monoubiquitination
- regulation of type I interferon production
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- RNA binding