St8sia4 Gene Summary [Mouse]
Enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Involved in sialylation. Predicted to be located in Golgi apparatus. Is expressed in several structures, including central nervous system; gut; hemolymphoid system gland; lung; and sensory organ. Orthologous to human ST8SIA4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | St8sia4 |
| Official Name | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 [Source:MGI Symbol;Acc:MGI:106018] |
| Ensembl ID | ENSMUSG00000040710 |
| Bio databases IDs | |
| Aliases | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 |
| Synonyms | LOC501189, PST, PST-1, Sialyltransferase, SIAT8-D, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4, ST8SIA-IV, ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse St8sia4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- glycosyltransferase family 29
- alpha-N-acetylneuraminate alpha-2,8-sialyltransferase
- sialyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- seizures
- systemic lupus erythematosus
- motor dysfunction or movement disorder
- preeclampsia
- primary biliary cirrhosis
- hydrocephalus
- Parkinson disease
role in cell
- expression in
- cell death
- apoptosis
- migration
- phosphorylation in
- proliferation
- growth
- differentiation
- loss
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse St8sia4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- N-glycan processing
- nervous system development
- protein glycosylation
- oligosaccharide metabolic process
- ganglioside biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- sialyltransferase activity
- sialic acid binding
- alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity