Ccr5 Gene Summary [Mouse]
Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in negative regulation of macrophage apoptotic process. Acts upstream of or within apoptotic process and defense response. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; West Nile fever; autoimmune disease (multiple); berylliosis; and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif chemokine receptor 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccr5 |
| Official Name | chemokine (C-C motif) receptor 5 [Source:MGI Symbol;Acc:MGI:107182] |
| Ensembl ID | ENSMUSG00000079227 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) receptor 5 |
| Synonyms | AM4-7, C-C motif chemokine receptor 5, CD195, Ckr5, Cmkbr5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccr5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- protein kinase binding
- C-C chemokine binding
- actin binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ccr5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Breast Cancer Regulation by Stathmin1
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Chemokine Signaling
- CREB Signaling in Neurons
- G-Protein Coupled Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- Molecular Mechanisms of Cancer
- NF-κB Activation by Viruses
- Pathogenesis of Multiple Sclerosis
- Phagosome Formation
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- obesity
- neoplasia
- epithelial neoplasia
- metastasis
- colitis
- epithelial cancer
- Huntington disease
- adjuvant arthritis
- infection
role in cell
- activation in
- cell death
- expression in
- adhesion
- apoptosis
- proliferation
- migration
- phosphorylation in
- quantity
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- endosomes
- plasma membrane extracellular face