Ccr5 Gene Summary [Mouse]
Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in negative regulation of macrophage apoptotic process. Acts upstream of or within apoptotic process and defense response. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; West Nile fever; autoimmune disease (multiple); berylliosis; and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif chemokine receptor 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccr5 |
| Official Name | chemokine (C-C motif) receptor 5 [Source:MGI Symbol;Acc:MGI:107182] |
| Ensembl ID | ENSMUSG00000079227 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) receptor 5 |
| Synonyms | AM4-7, C-C motif chemokine receptor 5, CD195, Ckr5, Cmkbr5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccr5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- protein kinase binding
- C-C chemokine binding
- actin binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ccr5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Breast Cancer Regulation by Stathmin1
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Chemokine Signaling
- CREB Signaling in Neurons
- G-Protein Coupled Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- Molecular Mechanisms of Cancer
- NF-κB Activation by Viruses
- Pathogenesis of Multiple Sclerosis
- Phagosome Formation
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- obesity
- neoplasia
- epithelial neoplasia
- metastasis
- colitis
- epithelial cancer
- Huntington disease
- adjuvant arthritis
- infection
phenotypes
- abnormal CD4-positive alpha beta T cell morphology
- abnormal CD8-positive alpha beta T cell morphology
- abnormal Ito cell morphology
- abnormal Kupffer cell morphology
- abnormal NK T cell physiology
- abnormal astrocyte physiology
- abnormal cardiovascular system physiology
- abnormal cellular extravasation
- abnormal conditioned taste aversion behavior
- abnormal cytokine level
- abnormal cytokine secretion
- abnormal glial cell physiology
- abnormal heart size
- abnormal hepatocyte physiology
- abnormal leukocyte adhesion
- abnormal leukocyte physiology
- abnormal locomotor behavior
- abnormal long term spatial reference memory
- abnormal nervous system physiology
- abnormal spatial learning
- altered response to myocardial infarction
- bronchiolitis
- corneal vascularization
- decreased NK cell number
- decreased T cell proliferation
- decreased inflammatory response
- decreased interleukin-1 beta secretion
- decreased interleukin-6 secretion
- decreased microglial cell activation
- decreased right ventricle systolic pressure
- decreased skeletal muscle glycogen level
- decreased susceptibility to Retroviridae infection
- decreased susceptibility to endotoxin shock
- decreased susceptibility to induced colitis
- decreased susceptibility to injury
- impaired exercise endurance
- impaired macrophage chemotaxis
- increased IgG1 level
- increased NK T cell number
- increased alcohol consumption
- increased fluid intake
- increased interferon-gamma secretion
- increased interleukin-4 secretion
- increased length of allograft survival
- increased physiological sensitivity to xenobiotic
- increased susceptibility to Coronaviridae infection
- increased susceptibility to bacterial infection
- increased susceptibility to fungal infection
- increased susceptibility to type IV hypersensitivity reaction
- liver failure
role in cell
- activation in
- cell death
- expression in
- adhesion
- apoptosis
- proliferation
- migration
- phosphorylation in
- quantity
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- endosomes
- plasma membrane extracellular face