CPLX3 Gene Summary [Human]
Predicted to enable SNARE binding activity. Predicted to be involved in regulation of neurotransmitter secretion and synaptic vesicle exocytosis. Predicted to be located in plasma membrane and synapse. Predicted to be part of SNARE complex. Predicted to be active in photoreceptor ribbon synapse and terminal bouton. Predicted to be anchored component of presynaptic active zone membrane and anchored component of synaptic vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CPLX3 |
| Official Name | complexin 3 [Source:HGNC Symbol;Acc:HGNC:27652] |
| Ensembl ID | ENSG00000213578 |
| Bio databases IDs | |
| Aliases | complexin 3 |
| Synonyms | complexin 3, CPX-III, ERGIC-53L, ERGL, Lamn1l, Lman1l, Nbla11589, RGD1560104 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CPLX3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- Synaphin protein
- Complexin_NTD
- neurotransmitter transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- synaptic vesicle membrane
- cellular membrane
- Plasma Membrane
- cytosol
- presynaptic membrane
- synapse
- ribbon synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CPLX3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- insulin secretion
- regulation of synaptic vesicle fusion to presynaptic membrane
- synaptic vesicle exocytosis
- visual perception
Cellular Component
Where in the cell the gene product is active
- terminal button
- SNARE complex
- cytosol
- synaptic vesicle membrane
- presynaptic active zone membrane
Molecular Function
What the gene product does at the molecular level
- neurotransmitter transporter activity
- syntaxin binding
- SNARE binding