Otub2 Gene Summary [Mouse]
Predicted to enable cysteine-type deubiquitinase activity and ubiquitin binding activity. Predicted to be involved in protein K11-linked deubiquitination; protein K48-linked deubiquitination; and protein K63-linked deubiquitination. Orthologous to human OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Otub2 |
| Official Name | OTU domain, ubiquitin aldehyde binding 2 [Source:MGI Symbol;Acc:MGI:1915399] |
| Ensembl ID | ENSMUSG00000021203 |
| Bio databases IDs | |
| Aliases | OTU domain, ubiquitin aldehyde binding 2 |
| Synonyms | 2010015L18Rik, 4930586I02RIK, C14ORF137, OTB2, OTU2, Otubain 2, OTU deubiquitinase, ubiquitin aldehyde binding 2, OTU domain, ubiquitin aldehyde binding 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Otub2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase C65 Otubain
- ubiquitin-specific protease
- enzyme
- protein binding
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- metastasis
- acute myeloid leukemia
- organismal death
- colorectal cancer
- colon adenocarcinoma
- colon epithelial cancer
role in cell
- expression in
- growth
- binding in
- apoptosis
- synthesis in
- activation in
- degradation in
- proliferation
- glycolysis in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Otub2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- protein K11-linked deubiquitination
- negative regulation of double-strand break repair
- proteolysis
- protein K48-linked deubiquitination
- protein K63-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- ubiquitin binding