Msi1 Gene Summary [Mouse]
Enables molecular condensate scaffold activity; poly(U) RNA binding activity; and protein homodimerization activity. Predicted to be involved in central nervous system development; regulation of translation; and response to hormone. Located in cytoplasm and nucleus. Is expressed in central nervous system; gonad; gut; sensory organ; and skin. Orthologous to human MSI1 (musashi RNA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Msi1 |
| Official Name | musashi RNA-binding protein 1 [Source:MGI Symbol;Acc:MGI:107376] |
| Ensembl ID | ENSMUSG00000054256 |
| Bio databases IDs | |
| Aliases | musashi RNA-binding protein 1 |
| Synonyms | m-Msi-1, Msi1h, Musahi1, MUSASHI 1, musashi RNA-binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Msi1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding activity, bridging
- protein homodimerization
- protein binding
- single-stranded RNA binding
- identical protein binding
- RNA binding
- poly(U) binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- invasive breast cancer
- tubulo-interstitial fibrosis
- ataxia
- tumorigenesis
- medulloblastoma
- brain cancer
- edema
- rheumatoid arthritis
- cerebral hemorrhage
role in cell
- number
- apoptosis
- proliferation
- expression in
- formation
- degeneration
- abnormal morphology
- cell cycle progression
- loss
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- polysomes
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Msi1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- regulation of translation
- central nervous system development
- nervous system development
- response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- mRNA binding
- poly(U) RNA binding