Dtx4 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including Notch signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in centrosome and nucleoplasm. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human DTX4 (deltex E3 ubiquitin ligase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dtx4 |
| Official Name | deltex 4, E3 ubiquitin ligase [Source:MGI Symbol;Acc:MGI:2672905] |
| Ensembl ID | ENSMUSG00000039982 |
| Bio databases IDs | |
| Aliases | deltex 4, E3 ubiquitin ligase |
| Synonyms | D930042H13, deltex 4, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 4, LRRGT00037, RNF155 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dtx4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in Deltex and TRIP12 homologues
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- WWE domain
- enzyme
- Domain found at the C-terminus of deltex-like
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Dtx4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dtx4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- Notch signaling pathway
- negative regulation of innate immune response
- regulation of type I interferon production
- proteasomal protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding