Fat1 Gene Summary [Mouse]
Involved in epithelial cell morphogenesis; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis; and lens development in camera-type eye. Acts upstream of or within actin filament organization; cell-cell adhesion; and establishment or maintenance of cell polarity. Located in cell junction; filopodium; and lamellipodium. Is active in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; embryo mesenchyme; and sensory organ. Used to study facioscapulohumeral muscular dystrophy and nephrotic syndrome. Human ortholog(s) of this gene implicated in colorectal cancer; esophagus squamous cell carcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and oral squamous cell carcinoma. Orthologous to human FAT1 (FAT atypical cadherin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fat1 |
| Official Name | FAT atypical cadherin 1 [Source:MGI Symbol;Acc:MGI:109168] |
| Ensembl ID | ENSMUSG00000070047 |
| Bio databases IDs | |
| Aliases | FAT atypical cadherin 1 |
| Synonyms | 2310038E12Rik, CDHF7, CDHR8, FAT, FAT atypical cadherin 1, Fath, hFat1, ME5, mFat1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bacterial cadherin-like domain
- cytoplasmic domain
- LamG
- Human growth factor-like EGF
- transmembrane domain
- Cadherin repeat-like domain
- EGF domain
- protein binding
- laminin G domain
- EGF repeat
- EGF_CA
- first cysteine-rich (Cys-1) domain of Dickkopf proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- proteinuria
- epithelial cancer
- liver cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- plasma cell myeloma
- major depression
- nephrosis
- hepatocellular carcinoma
role in cell
- phosphorylation in
- expression in
- migration
- apoptosis
- density
- growth
- proliferation
- formation in
- survival
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- cilia
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- Mitochondria
- intercellular junctions
- cytosol
- apical membrane
- anchoring junction
- filopodia
- cell-cell adherens junctions
- podocyte slit diaphragm
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis
- establishment or maintenance of cell polarity
- epithelial cell morphogenesis
- cell-cell signaling
- actin filament organization
- anatomical structure morphogenesis
- cell adhesion
- homophilic cell adhesion
- lens development in camera-type eye
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cell-cell junction
- focal adhesion
- cytosol
- filopodium
- apical plasma membrane
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding