Unc45a Gene Summary [Mouse]
Enables Hsp90 protein binding activity. Acts upstream of or within chaperone-mediated protein folding. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and retina. Orthologous to human UNC45A (unc-45 myosin chaperone A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Unc45a |
| Official Name | unc-45 myosin chaperone A [Source:MGI Symbol;Acc:MGI:2142246] |
| Ensembl ID | ENSMUSG00000030533 |
| Bio databases IDs | |
| Aliases | unc-45 myosin chaperone A |
| Synonyms | GC-UNC45, IRO039700, OOHE, RGD1305357, SMAP-1, unc-45 myosin chaperone A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Unc45a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Myosin-binding striated muscle assembly central
- TPR repeat
- Tetratricopeptide repeats
- heat shock protein binding
- protein binding
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- osteo-oto-hepato-enteric syndrome
- cholestasis-lymphedema syndrome
- congenital diarrhea disorder
- infection by Influenza A virus subtype H1N1
regulated by
- TP53
- TAF6
role in cell
- expression in
- quantity
- proliferation
- morphogenesis
- curvature
- centrosome separation in
- disorganization in
- amplification in
- misfolding in
- metaphase in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear region
- Nucleus
- Golgi Apparatus
- cytosol
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Unc45a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- chaperone-mediated protein folding
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- nuclear speck
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- Hsp90 protein binding