Tax1bp3 Gene Summary [Mouse]
Enables beta-catenin binding activity. Involved in negative regulation of Wnt signaling pathway. Acts upstream of or within negative regulation of cell population proliferation. Located in cytoplasm and nucleus. Is expressed in retina. Orthologous to human TAX1BP3 (Tax1 binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tax1bp3 |
| Official Name | Tax1 (human T cell leukemia virus type I) binding protein 3 [Source:MGI Symbol;Acc:MGI:1923531] |
| Ensembl ID | ENSMUSG00000040158 |
| Bio databases IDs | |
| Aliases | Tax1 (human T cell leukemia virus type I) binding protein 3 |
| Synonyms | 1300011C24Rik, Tax1 binding protein 3, Tax1 (human T cell leukaemia virus type I) binding protein 3, Tax1 (human T cell leukemia virus type I) binding protein 3, TAX INTERACTION protein 1, TIP-1, Vesicle docking |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tax1bp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- transcription regulator
- beta-catenin binding
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- Duchenne muscular dystrophy
- schizophrenia
- autosomal dominant Emery-Dreifuss muscular dystrophy
- juvenile dermatomyositis
role in cell
- growth
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- intracellular membrane-bounded organelle
- actin cytoskeleton
- Nucleus
- cytosol
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tax1bp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein localization at cell surface
- negative regulation of cell proliferation
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- Rho protein signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- actin cytoskeleton
- cytosol
- fibrillar center
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-catenin binding