Emp3 Gene Summary [Mouse]
Predicted to be involved in apoptotic process and bleb assembly. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; hemolymphoid system; musculoskeletal system; nervous system; and sensory organ. Orthologous to human EMP3 (epithelial membrane protein 3 (MAM blood group)). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Emp3 |
| Official Name | epithelial membrane protein 3 [Source:MGI Symbol;Acc:MGI:1098729] |
| Ensembl ID | ENSMUSG00000040212 |
| Bio databases IDs | |
| Aliases | epithelial membrane protein 3 |
| Synonyms | epithelial membrane protein 3, epithelial membrane protein 3 (MAM blood group), H-4, haematoPOIETIC NEURAL MEMBRANE, HEMATOPOIETIC NEURAL MEMBRANE, HNMP-1, MI-35, YMP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Emp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PMP-22/EMP/MP20/Claudin family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- pervasive developmental disorder
- juvenile dermatomyositis
- skin cancer
- endometrial cancer
- overall survival
role in cell
- phosphorylation in
- expression in
- cell death
- proliferation
- migration
- apoptosis
- degradation in
- epithelial-mesenchymal transition
- formation by
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- cellular protrusions
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Emp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bleb assembly
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding