Olfm2 Gene Summary [Mouse]
Involved in neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within locomotory behavior and visual perception. Located in synaptic membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Is expressed in several structures, including central nervous system; eye; and orbito-sphenoid. Orthologous to human OLFM2 (olfactomedin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Olfm2 |
| Official Name | olfactomedin 2 [Source:MGI Symbol;Acc:MGI:3045350] |
| Ensembl ID | ENSMUSG00000032172 |
| Bio databases IDs | |
| Aliases | olfactomedin 2 |
| Synonyms | A030009A06, A030009A06Rik, NOE2, NOELIN2, NOELIN2 V1, olfactomedin 2, OlfC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Olfm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Olfactomedin-like domain
- Neurogenesis glycoprotein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- Extracellular Space
- Nucleus
- Plasma Membrane
- synaptic membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Olfm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of smooth muscle cell differentiation
- protein secretion
Cellular Component
Where in the cell the gene product is active
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
- nucleus
- extracellular space
- cytoplasm
- synapse
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding