Eps8l3 Gene Summary [Mouse]
Predicted to enable actin binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in ruffle membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypotrichosis 5. Orthologous to human EPS8L3 (EPS8 signaling adaptor L3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eps8l3 |
| Official Name | EPS8-like 3 [Source:MGI Symbol;Acc:MGI:2139743] |
| Ensembl ID | ENSMUSG00000040600 |
| Bio databases IDs | |
| Aliases | EPS8-like 3 |
| Synonyms | EPS8-like 3, EPS8R3, EPS8 signaling adaptor L3, HYPT5, MUHH2, NEWGENE 1308310 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eps8l3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SAM (Sterile alpha motif )
- guanyl-nucleotide exchange factor
- SAM domain (Sterile alpha motif)
- protein binding
- Pleckstrin homology-like domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eps8l3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rho protein signal transduction
- Rho protein signal transduction
- positive regulation of ruffle assembly
- regulation of hair cycle
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- ruffle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- actin binding
- guanyl-nucleotide exchange factor activity