Pla2g2d

Enables calcium-dependent phospholipase A2 activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Involved in glycerophospholipid metabolic process and regulation of acute inflammatory response to antigenic stimulus. Acts upstream of or within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation and negative regulation of T cell proliferation. Located in extracellular region. Is expressed in several structures, including alimentary system; brain; gonad; hemolymphoid system gland; and lung. Orthologous to human PLA2G2D (phospholipase A2 group IID). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pla2g2d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Pla2g2d gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.