Rbbp8 Gene Summary [Mouse]
Predicted to enable several functions, including identical protein binding activity; single-stranded DNA endodeoxyribonuclease activity; and transcription corepressor activity. Acts upstream of or within G1/S transition of mitotic cell cycle and blastocyst hatching. Predicted to be located in nucleoplasm. Predicted to be part of BRCA1-C complex and transcription repressor complex. Predicted to be active in site of double-strand break. Human ortholog(s) of this gene implicated in Seckel syndrome 2. Orthologous to human RBBP8 (RB binding protein 8, endonuclease). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbbp8 |
| Official Name | retinoblastoma binding protein 8, endonuclease [Source:MGI Symbol;Acc:MGI:2442995] |
| Ensembl ID | ENSMUSG00000041238 |
| Bio databases IDs | |
| Aliases | retinoblastoma binding protein 8, endonuclease |
| Synonyms | 9930104E21RIK, COM1, CTIP, JAWAD, JWDS, RB binding protein 8, endonuclease, Rbbp8-rs, retinoblastoma binding protein 8, endonuclease, RGD1308872, RIM, SAE2, SCKL2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbbp8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CtBP binding domain
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- transcription co-repressor
- DNA endonuclease activator SAE2/CtIP C-terminus
- transcription factor binding
- cdk phosphorylation site
- coiled-coil domain
- enzyme
- protein binding
- LXCXE binding site
- identical protein binding
- retinoblastoma protein binding domain
- single-stranded DNA specific endodeoxyribonuclease
- Tumour-suppressor protein CtIP N-terminal domain
- damaged DNA binding
Pathways
Biological processes and signaling networks where the Rbbp8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- hematologic cancer
- lymphomagenesis
- cancer
- hematological neoplasia
- lymphoid cancer
- lymphatic neoplasia
- epithelial cancer
- gastric cancer
- breast carcinoma
role in cell
- apoptosis
- activation in
- binding in
- cell viability
- growth
- expression in
- proliferation
- formation
- formation in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbbp8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- DNA repair
- meiotic cell cycle
- DNA double-strand break processing involved in repair via single-strand annealing
- negative regulation of transcription, DNA-dependent
- blastocyst hatching
- G1/S transition of mitotic cell cycle
- double-strand break repair via homologous recombination
- reciprocal DNA recombination
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- transcriptional repressor complex
- intracellular membrane-bounded organelle
- BRCA1-C complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transcription corepressor activity
- metal ion binding
- damaged DNA binding
- single-stranded DNA specific endodeoxyribonuclease activity