Ssr2 Gene Summary [Mouse]
Acts upstream of or within in utero embryonic development. Predicted to be located in endoplasmic reticulum membrane. Is expressed in cranium; genitourinary system; and pancreas epithelium. Orthologous to human SSR2 (signal sequence receptor subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ssr2 |
| Official Name | signal sequence receptor, beta [Source:MGI Symbol;Acc:MGI:1913506] |
| Ensembl ID | ENSMUSG00000041355 |
| Bio databases IDs | |
| Aliases | signal sequence receptor, beta |
| Synonyms | 1500032E05Rik, HSD25, signal sequence receptor, beta, signal sequence receptor subunit 2, Signal sequence receptor β, signal sequence receptor, β, SSR-beta, SSR-β, TLAP, translocon-associated protein beta, translocon-associated protein β, TRAPB, TRAP-BETA, TRAP-β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ssr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Translocon-associated protein beta (TRAPB)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- CYP51A1
disease
- non-small cell lung cancer
- non-small cell lung carcinoma
phenotypes
- abnormal Wolffian duct morphology
- abnormal atrioventricular septum morphology
- abnormal diaphragm morphology
- abnormal digastric muscle morphology
- abnormal ductus venosus valve morphology
- abnormal eye muscle morphology
- abnormal forebrain morphology
- abnormal hepatic vein connection
- abnormal hyoid bone greater horn morphology
- abnormal hypoglossal nerve topology
- abnormal inferior vena cava valve morphology
- abnormal infrahyoid muscle connection
- abnormal interatrial septum morphology
- abnormal optic chiasm morphology
- abnormal optic cup morphology
- abnormal optic nerve morphology
- abnormal optic stalk morphology
- abnormal placental labyrinth vasculature morphology
- abnormal pulmonary valve cusp morphology
- abnormal thymus morphology
- absent ductus venosus valve
- basisphenoid bone foramen
- common truncal valve
- dilated lateral ventricles
- double outlet right ventricle
- enlarged liver sinusoidal spaces
- enlarged third ventricle
- fetal growth retardation
- fusion of vertebral arches
- hemopericardium
- heterochrony
- interrupted aortic arch type b
- intracerebral hemorrhage
- muscular ventricular septal defect
- perimembraneous ventricular septal defect
- persistent truncus arteriosis
- preweaning lethality complete penetrance
- reduced sympathetic cervical ganglion size
- scoliosis
- small superior cervical ganglion
- subcutaneous edema
- thin myocardium compact layer
- trigeminal neuroma
role in cell
- endoplasmic reticulum-associated degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ssr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cotranslational protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding