Mcm9 Gene Summary [Mouse]
Enables chromatin binding activity. Involved in DNA repair and female gamete generation. Part of MCM8-MCM9 complex. Is expressed in several structures, including brain; genitourinary system; liver; neural retina; and spleen. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in ovarian dysgenesis 4. Orthologous to human MCM9 (minichromosome maintenance 9 homologous recombination repair factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcm9 |
| Official Name | minichromosome maintenance 9 homologous recombination repair factor [Source:MGI Symbol;Acc:MGI:1918817] |
| Ensembl ID | ENSMUSG00000058298 |
| Bio databases IDs | |
| Aliases | minichromosome maintenance 9 homologous recombination repair factor |
| Synonyms | 9030408O17Rik, C6ORF61, dJ329L24.1, dJ329L24.3, FLJ20170, Gm235, MCMDC1, minichromosome maintenance 9 homologous recombination repair factor, ODG4, RGD1560557 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcm9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme binding
- MCM P-loop domain
- chromatin binding
- enzyme
- protein binding
- MCM AAA-lid domain
- DNA helicase
- MCM helicase family
- minichromosome maintenance proteins
- AAA domain (dynein-related subfamily)
- MCM OB domain
- ATPase family associated with various cellular activities (AAA)
- binding protein
- BRCv motif
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Mcm9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiomyopathy
- ovarian dysgenesis type 4
- premature ovarian failure type 1
- major depression
- oligozoospermia
role in cell
- proliferation
- apoptosis
- formation
- growth
- abnormal morphology
- DNA damage response
- breakage
- gametogenesis
- generation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcm9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- female gamete generation
- mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
- protein localization to chromatin
- DNA replication
- DNA duplex unwinding
- double-strand break repair via homologous recombination
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- MCM complex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- MutSalpha complex binding
- MutSbeta complex binding
- ATP binding
- DNA helicase activity
- MutLbeta complex binding
- protein binding
- chromatin binding
- single-stranded DNA-dependent ATP-dependent DNA helicase activity
- enzyme binding
- single-stranded DNA binding