Alg13 Gene Summary [Mouse]
Predicted to enable N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity. Acts upstream of or within negative regulation of TORC1 signaling and regulation of synaptic plasticity. Located in cytoplasm. Is expressed in several structures, including forelimb bud; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 36. Orthologous to human ALG13 (ALG13 UDP-N-acetylglucosaminyltransferase subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alg13 |
| Official Name | asparagine-linked glycosylation 13 [Source:MGI Symbol;Acc:MGI:1914824] |
| Ensembl ID | ENSMUSG00000041718 |
| Bio databases IDs | |
| Aliases | asparagine-linked glycosylation 13 |
| Synonyms | 2810046O15Rik, 4833435D08Rik, ALG13 UDP-N-acetylglucosaminyltransferase subunit, asparagine-linked glycosylation 13, CDG1S, CXorf45, DEE36, EIEE36, GLT28D1, LOC100503426, MDS031, TDRD13, YGL047W |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alg13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase
- enzyme
- protein binding
- Tudor domain superfamily
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- developmental epileptic encephalopathy
- congenital disorders of glycosylation
- mental retardation
- idiopathic scoliosis
- early missed abortion
- microcephaly
- epilepsy
regulated by
- TCR (complex)
- CELF2
regulates
- MTORC1
- oligosaccharide-diphosphodolichol
- Carboxypeptidase Y
role in cell
- growth
- plasticity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Alg13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- protein N-linked glycosylation
- dolichol-linked oligosaccharide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity